Mutational profile of immunoglobulin heavy chain genes of chronic lymphocytic leukemia and diffuse large B-cell lymphoma in Richter’s syndrome Ph.D. theses

نویسنده

  • Botond Timár
چکیده

s: Timar B, Chadburn A, Knowles DM, Cesarman E: The alternative NF-κB pathway is active in the majority of diffuse large B-cell lymphomas. Laboratory Investigation 2006 (86): 248A IF: 3.702 Timar B, Chadburn A, Knowles DM, Cesarman E: Activation of classical and alternative nuclear factor-kappaB (NF-κB) pathways in diffuse large Bcell lymphomas. Blood 104 (11): 12A-13A 29 Part 1 NOV 16 2004 IF: 9.782 Matolcsy A, Csernus B, Fülöp Zs, Timár B, Jakso P, Kopper L: Mutational analysis of IgH and BCL-6 genes suggests thymic B-cell origin of mediastinal B-cell lymphoma. Ann Oncol 2002, 13 (suppl 2):128. IF: 3.114 Timár B, Fülöp Zs, Csernus B, Matolcsy A: Analysis of the methylation in lymphomas with the cytosine extension assay. Magyar Onkológia 2002, 46:104. 10 Csernus B, Timár B, Fülöp Zs, Jáksó P, Matolcsy A: Mutational analysis of IgH and BCL-6 genes suggests thymic B-cell origin of mediastinal B-cell lymphoma. Magyar Onkológia 2002, 46:90. Fülöp Zs, Csernus B, Timár B, Matolcsy A: The role of genetic instability and hMLH1 promoter hypermethylation in the Richter's transformation of chronic lymphocytic leukemia. Magyar Onkológia 2002, 46:92.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

A systematic review evaluating the efficacy of autologous hematopoietic transplantation for diffuse large B cell lymphoma-type Richter syndrome

Background: Chronic lymphocytic leukemia (CLL) can transform into fast growing lymphoma for diffuse large B-cell lymphoma (DLBCL) called Richter's syndrome (RS), which is commonly related to an existence of large B-cells with equal or larger size than macrophage nuclei or more than twice those of normal lymphocyte. We conducted a systematic review of the existing literature to assess the clinic...

متن کامل

Chronic lymphocytic leukemia: ESMO minimum clinical recommendations for diagnosis, treatment and follow-up.

The diagnosis of CLL is established by a sustained increase of peripheral CD5+ B-lymphocytes (‡5 · 10 cells/l) not explained by other clinical disorders and a predominance of small, morphologically mature lymphocytes in the blood smear. The composite immunophenotype CD5+, CD19+, CD20+ (low), CD23+, sIg low, CD79b low, FMC7– allows most cases of CLL to be distinguished from other CD5+ B-cell lym...

متن کامل

Diffuse Large B-Cell Lymphoma as a Sequela of Sjögren’s Syndrome: A Case Report

We present a case of a 45-year-old woman with primary Sjögren's syndrome, who in 2005, one year after the onset of the systemic autoimmune disease developed chronic lymphocytic leukaemia, which eventually transformed denoted as Richter’s transformation into diffuse large B-cell lymphoma in 2006. She had recurrent lymphadenopathy on the neck region from 2002. In September 2005 anaemia and elevat...

متن کامل

Concomitant Presence of CD5-Positive Diffuse Large B-Cell Lymphoma and Monoclonal B Cells with the “CLL Immunophenotype” - Is It Richter’s Transformation?

The presence of diffuse large B-cell lymphoma (DLBCL) with a concomitant unsuspected population of B cells with chronic lymphoid leukemia (CLL) phenotype is very rare with no antecedent history of CLL. This may represent cases of de novo Richter’s transformation or the coexistence of two neoplasms [1]. In cases where the monoclonal B-cell population does not exceed 5x109/L, this may represent D...

متن کامل

ZAP-70 expression in B-cell hematologic malignancy is not limited to CLL/SLL.

ZAP-70 is a tyrosine kinase expressed in normal T cells and NK cells. Expression of ZAP-70 has been associated with poor prognosis in B-cell chronic lymphocytic leukemia and might be a surrogate marker for immunoglobin heavy chain (IGH) mutational status in that disease. Little is known about ZAP-70 expression in other hematologic malignant neoplasms. We examined 446 specimens representing a ra...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2006